… crystal structures that reveal the crucial interactions made by … As such, it is a target for strand
transfer inhibitors, which are a … high-resolution cocrystal structures of a two-domain HIV-1 IN …

… 3′-processing), binds cellular target DNA and carries out the … The catalytic core domain is
the most stable and conservative … effect on HIV replication, possibly by weakening integrase …

… -1 integrase was shown to commit to substrate DNA within 1 … have implications for the rational
design of HIV-1 IN targeting … (A) Crystal structure of the target capture complex TCC (PDB: …

… Integrase is an attractive target for HIV-1 treatment due to the … Its crystal structure remains
unknown due to the low solubility … owing to its cytotoxic effect. The moieties presented in …

… Chapter 1 discusses the background and significance of HIV … focus on strategies to specifically
target integrase in an effort to … The X-ray crystal structure of the IN catalytic core domain in …

… domains the N terminal domain (residues 1-50), the catalytic … Raltegravir shown interaction
with catalytic amino acid … activities with viral LTR DNA and target DNA compared to the wild …

… The complex crystal structure of HTLV-1 integrase (PDB ID = … strength of interactions between
a molecule and its specific target, … The effect of solvent molecules on polar groups, which …

… (NTD) comprising residues 1–46, the catalytic core domain (… strand transfer inhibitors (INSTIs)
have been developed to target … In our study, the structural alteration had no effect on drug …

… target sequence, relative to other templates from prototype foamy viruses. However, crystal
structures … involved in the catalytic activity of the HIV-1 IN catalytic core domain. Several force …

… a) in the catalytic core domain (CCD) of integrase. The two … integrase crystal structure, 16
and because of the two-metal … inhibitors targeting the catalytic site of IN with a specific effect …